Guanethidine sulfate
Guanethidine Monosulfate
CAS: 645-43-2
Molecular Formula: C10H24N4O4S
Guanethidine sulfate - Names and Identifiers
| Name | Guanethidine Monosulfate |
| Synonyms | Guanethidine sulfate GUANETHIDINE SULFATE Guanethidine Sulphae Guanethidine Monosulfate GUANETHIDINE MONOSULFATE n-(2-guanidinoethyl)heptamethyleniminesulfate 2-(octahydro-1-azocinyl)ethylguanidinesulphate (2-(hexahydro-1(2h)-azocinyl)ethyl)guanidinehydrogensulfate |
| CAS | 645-43-2 |
| EINECS | 211-442-0 |
| InChI | InChI=1/C10H22N4.H2O4S/c11-10(12)13-6-9-14-7-4-2-1-3-5-8-14;1-5(2,3)4/h1-9H2,(H4,11,12,13);(H2,1,2,3,4) |
| InChIKey | YUFWAVFNITUSHI-UHFFFAOYSA-N |
Guanethidine sulfate - Physico-chemical Properties
| Molecular Formula | C10H24N4O4S |
| Molar Mass | 296.39 |
| Melting Point | 276-281 °C |
| Solubility | Freely soluble in water, practically insoluble in ethanol (96 per cent) |
| Appearance | Solid |
| Color | White to Off-White |
| Storage Condition | 2-8°C |
| Stability | Hygroscopic |
Guanethidine sulfate - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 22 - Harmful if swallowed |
| Safety Description | S25 - Avoid contact with eyes. S36 - Wear suitable protective clothing. |
| RTECS | MF3150000 |
| HS Code | 2933999552 |
Guanethidine sulfate - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.374 ml | 16.87 ml | 33.739 ml |
| 5 mM | 0.675 ml | 3.374 ml | 6.748 ml |
| 10 mM | 0.337 ml | 1.687 ml | 3.374 ml |
| 5 mM | 0.067 ml | 0.337 ml | 0.675 ml |
Last Update：2024-01-02 23:10:35
Guanethidine sulfate - Reference Information
| biological activity | Guanethidine sulfate is an antihypertensive drug. Guanethidine sulfate is also an Adrenergic neuron-blocking drug that enters noradrenergic nerve endings via neuronal amine carriers. |
| Animal Model: | Male Wistar rats (approximately 200 g) |
| Dosage: | 5 mg/kg or 40 mg/kg |
| Administration: | Intraperitoneal injection; daily; for 4, 8, 14, or 28 days |
| Result: | Lowered the blood pressure by 40 mg/kg, the decrease being reversible on discontinuation. The hypersensitivity was partly reversible on discontinuation, but a significantly increased sensitivity of the heart rate to noradrenaline was observed 60 days after discontinuation by 40 mg/kg for 28 days. Histologically a profound loss of nerve cells of the superior cervical ganglion was observed by 40 mg/kg. |
| Usage | is an adrenoceptin nerve blocking agent. Its function is to interfere with the sympathetic nerve endings to the adrenal glands. The release of the hormone also depletes the noradrenals. The storage of hormones, thus when the adrenal glands. When the primary nerve Impulse reaches the periphery, there is no enough medium to transmit, sympathetic nerve activity decreases, blood pressure decreases, and its hypotensive effect is strong and lasting. Mainly for moderate and severe high diastolic blood pressure, hypertension and renal hypertension more stubborn. |
Last Update：2024-04-09 21:04:16
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View History
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